Cochlin (COCH) Peptide
COCH
Reactivité: Mammifères
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN936639
Aperçu rapide pour Cochlin (COCH) Peptide (ABIN936639)
Antigène
COCH
(Cochlin (COCH))
Origine
Mammifères
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Type de proteíne
- Synthetic
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Séquence
- AHPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR FNLQKNFVGK
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Attributs du produit
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A synthetic peptide for use as a blocking control in assays to test for specificity of COCH antibody,
Alternative Names: COCH control peptide, COCH antibody Blocking Peptide, Anti-COCH Blocking Peptide, coagulation factor C homolog, cochlin, Limulus polyphemus Blocking Peptide, COCH-5B2 Blocking Peptide, COCH5B2 Blocking Peptide, DFNA9 Blocking Peptide
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Indications d'application
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- Store at -20 °C long term.
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- COCH (Cochlin (COCH))
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Sujet
- The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 74 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
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Poids moléculaire
- 57 kDa
Antigène
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